mei 25, 2024

Modification of non-ribosomal peptides by adenylation Area

lotuskringpoeldijk

Environment friendly rational modification of non-ribosomal peptides by adenylation area substitution

Non-ribosomal peptide synthetase (NRPS) enzymes kind modular assembly-lines, whereby every module governs the incorporation of a particular monomer into a brief peptide product. Modules are comprised of a number of key domains, together with adenylation (A) domains, which recognise and activate the monomer substrate; condensation (C) domains, which catalyse amide bond formation; and thiolation (T) domains, which shuttle response intermediates between catalytic domains.

 This association provides prospects for rational peptide modification by way of substitution of substrate-specifying domains. For over 20 years, it has been thought-about that C domains play key roles in proof-reading the substrate; a presumption that has enormously difficult rational NRPS redesign.

Right here we current proof from each directed and pure evolution research that any substrate-specifying function for C domains is prone to be the exception reasonably than the rule, and that novel non-ribosomal peptides will be generated by substitution of A domains alone. We establish permissive A site recombination boundaries and present that these permit us to effectively generate modified pyoverdine peptides at excessive yields. We additional display the transferability of our method within the PheATE-ProCAT mannequin system initially used to deduce C area substrate specificity, producing modified dipeptide merchandise at yields which are inconsistent with the prevailing dogma.

lotuskringpoeldijk
lotuskringpoeldijk

MYBPC1 Blocking Peptide

MBS8221402-5x5mg 5x5mg
EUR 1465

MYBPC1 Blocking Peptide

MBS9624370-1mg 1mg
EUR 380

MYBPC1 Blocking Peptide

MBS9624370-5x1mg 5x1mg
EUR 1650

MYBPC1 Peptide - N-terminal region

MBS3246628-01mg 0.1mg
EUR 180

MYBPC1 Peptide - N-terminal region

MBS3246628-5x01mg 5x0.1mg
EUR 730

MYBPC1 Antibody (Center) Blocking Peptide

MBS9222452-INQUIRE INQUIRE Ask for price

AAP82044-100UG - MYBPC1 Peptide - N-terminal region

AAP82044-100UG 100ug
EUR 99

MYBPC2 Peptide

5651P 0.05 mg
EUR 197.7
Description: (CT) MYBPC2 peptide

MYBPC2 Peptide

MBS152349-005mg 0.05mg
EUR 175

MYBPC2 Peptide

MBS152349-5x005mg 5x0.05mg
EUR 770

MYBPC2 Blocking Peptide

20-abx064180
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  • 1 mg
  • 5 mg

MYBPC2 Blocking Peptide

33R-4316 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MYBPC2 antibody, catalog no. 70R-6055

MYBPC3 Blocking Peptide

DF8063-BP 1mg
EUR 234

MYBPC2 Blocking Peptide

DF9649-BP 1mg
EUR 234

MYBPC2 Blocking Peptide

MBS822951-1mg 1mg
EUR 190

MYBPC2 Blocking Peptide

MBS822951-5mg 5mg
EUR 345

MYBPC2 Blocking Peptide

MBS822951-5x5mg 5x5mg
EUR 1465

MYBPC3 Blocking Peptide

MBS8247788-1mg 1mg
EUR 190

MYBPC3 Blocking Peptide

MBS8247788-5mg 5mg
EUR 345

MYBPC3 Blocking Peptide

MBS8247788-5x5mg 5x5mg
EUR 1465

MYBPC3 Blocking Peptide

MBS9627242-1mg 1mg
EUR 380

MYBPC3 Blocking Peptide

MBS9627242-5x1mg 5x1mg
EUR 1650

MYBPC2 Blocking Peptide

MBS9628670-1mg 1mg
EUR 380

MYBPC2 Blocking Peptide

MBS9628670-5x1mg 5x1mg
EUR 1650

MYBPC3 Peptide - C-terminal region

MBS3230772-01mg 0.1mg
EUR 180

MYBPC3 Peptide - C-terminal region

MBS3230772-5x01mg 5x0.1mg
EUR 730

MYBPC2 Peptide - N-terminal region

MBS3231199-01mg 0.1mg
EUR 180

MYBPC2 Peptide - N-terminal region

MBS3231199-5x01mg 5x0.1mg
EUR 730

MYBPC3 Antibody (N-term) Blocking peptide

MBS9219123-INQUIRE INQUIRE Ask for price

AAP41377-100UG - MYBPC3 Peptide - C-terminal region

AAP41377-100UG 100ug
EUR 99

AAP42187-100UG - MYBPC2 Peptide - N-terminal region

AAP42187-100UG 100ug
EUR 99

MYBPC1 siRNA

20-abx925094
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  • Ask for price
  • 15 nmol
  • 30 nmol

MYBPC1 siRNA

20-abx925095
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

MYBPC1 Antibody

6679-002mg 0.02 mg
EUR 206.18
Description: MYBPC1 Antibody: Myosin binding protein C (MYBPC) is a component of the thick filament of striated muscle, with the slow-type isoform designated MYBPC1. Both the fast-type (MYBPC2) and slow-type MYBPC protein contains seven immunoglobulin C2 motifs and three fibronectin type-III repeats. Multiple isoforms of MYBPC1 are known to exist, and are present in varying amounts in different skeletal muscles. It is thought that the MYBPC1 slow subfamily may play important roles in the assembly and stabilization of sarcomeric M- and A-bands and regulate the contractile properties of the actomyosin filaments.

MYBPC1 Antibody

6679-01mg 0.1 mg
EUR 523.7
Description: MYBPC1 Antibody: Myosin binding protein C (MYBPC) is a component of the thick filament of striated muscle, with the slow-type isoform designated MYBPC1. Both the fast-type (MYBPC2) and slow-type MYBPC protein contains seven immunoglobulin C2 motifs and three fibronectin type-III repeats. Multiple isoforms of MYBPC1 are known to exist, and are present in varying amounts in different skeletal muscles. It is thought that the MYBPC1 slow subfamily may play important roles in the assembly and stabilization of sarcomeric M- and A-bands and regulate the contractile properties of the actomyosin filaments.

MYBPC1 Antibody

25418 100ul
EUR 479

MYBPC1 Antibody

25418-100ul 100ul
EUR 468

MYBPC1 Antibody

25449 100ul
EUR 479

MYBPC1 Antibody

25449-100ul 100ul
EUR 468

MYBPC1 Antibody

34821 100ul
EUR 319

MYBPC1 Antibody

34821-100ul 100ul
EUR 302.4

MYBPC1 Antibody

34821-50ul 50ul
EUR 224.4

MYBPC1 Antibody

E034821 100μg/100μl
EUR 255
Description: Available in various conjugation types.

MYBPC1 Antibody

E11-16778C 100μg
EUR 225
Description: Available in various conjugation types.

MYBPC1 Antibody

E19-4198 100μg/100μl
EUR 225
Description: Available in various conjugation types.

MYBPC1 Antibody

DF4198 200ul
EUR 420

MYBPC1 Antibody

DF4198-100ul 100ul
EUR 280

MYBPC1 Antibody

DF4198-200ul 200ul
EUR 350

MYBPC1 Antibody

E38PA4103 100ul
EUR 225
Description: Available in various conjugation types.

MYBPC1 Antibody

5649-002mg 0.02 mg
EUR 206.18
Description: MYBPC1 Antibody: Myosin binding protein C (MYBPC) is a component of the thick filament of striated muscle, with the slow-type isoform designated MYBPC1. Both the fast-type (MYBPC2) and slow-type MYBPC protein contains seven immunoglobulin C2 motifs and three fibronectin type-III repeats. Multiple isoforms of MYBPC1 are known to exist, and are present in varying amounts in different skeletal muscles. It is thought that the MYBPC1 slow subfamily may play important roles in the assembly and stabilization of sarcomeric M- and A-bands and regulate the contractile properties of the actomyosin filaments.

MYBPC1 Antibody

5649-01mg 0.1 mg
EUR 523.7
Description: MYBPC1 Antibody: Myosin binding protein C (MYBPC) is a component of the thick filament of striated muscle, with the slow-type isoform designated MYBPC1. Both the fast-type (MYBPC2) and slow-type MYBPC protein contains seven immunoglobulin C2 motifs and three fibronectin type-III repeats. Multiple isoforms of MYBPC1 are known to exist, and are present in varying amounts in different skeletal muscles. It is thought that the MYBPC1 slow subfamily may play important roles in the assembly and stabilization of sarcomeric M- and A-bands and regulate the contractile properties of the actomyosin filaments.

MYBPC1 antibody

70R-35344 100 ug
EUR 294
Description: Purified Rabbit polyclonal MYBPC1 antibody

MYBPC1 Antibody

1-CSB-PA010297
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  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against MYBPC1. Recognizes MYBPC1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

MYBPC1 Antibody

1-CSB-PA717389LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against MYBPC1. Recognizes MYBPC1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:500-1:1000, IF:1:200-1:500

MYBPC1 Antibody

ABD4198 100ug
EUR 325

MYBPC1 Antibody

MBS7106065-005mg 0.05mg
EUR 190

MYBPC1 Antibody

MBS7106065-01mg 0.1mg
EUR 270

MYBPC1 Antibody

MBS7106065-5x01mg 5x0.1mg
EUR 1205

MYBPC1 Antibody

MBS7118449-005mg 0.05mg
EUR 150

MYBPC1 Antibody

MBS7118449-01mg 0.1mg
EUR 190

MYBPC1 Antibody

MBS7118449-5x01mg 5x0.1mg
EUR 845

MYBPC1 Antibody

MBS9412747-005mL 0.05mL
EUR 245

MYBPC1 Antibody

MBS9412747-01mL 0.1mL
EUR 305

MYBPC1 Antibody

MBS9412747-5x01mL 5x0.1mL
EUR 1230

MYBPC1 Antibody

MBS9414467-01mL 0.1mL
EUR 495

MYBPC1 Antibody

MBS9414467-5x01mL 5x0.1mL
EUR 2075

MYBPC1 Antibody

MBS9411751-01mL 0.1mL
EUR 495

MYBPC1 Antibody

MBS9411751-5x01mL 5x0.1mL
EUR 2075

MYBPC1 Antibody

MBS856317-01mg 0.1mg
EUR 305

MYBPC1 Antibody

MBS856317-01mLAF405L 0.1mL(AF405L)
EUR 465

MYBPC1 Antibody

MBS856317-01mLAF405S 0.1mL(AF405S)
EUR 465

MYBPC1 Antibody

MBS856317-01mLAF610 0.1mL(AF610)
EUR 465

MYBPC1 Antibody

MBS856317-01mLAF635 0.1mL(AF635)
EUR 465

MYBPC1 Antibody

MBS8582320-01mL 0.1mL
EUR 305

MYBPC1 Antibody

MBS8582320-01mLAF405L 0.1mL(AF405L)
EUR 465

MYBPC1 Antibody

MBS8582320-01mLAF405S 0.1mL(AF405S)
EUR 465

MYBPC1 Antibody

MBS8582320-01mLAF610 0.1mL(AF610)
EUR 465

MYBPC1 Antibody

MBS8582320-01mLAF635 0.1mL(AF635)
EUR 465

MYBPC1 Antibody

MBS8514903-01mg 0.1mg
EUR 305

MYBPC1 Antibody

MBS8514903-01mLAF405L 0.1mL(AF405L)
EUR 465

MYBPC1 Antibody

MBS8514903-01mLAF405S 0.1mL(AF405S)
EUR 465

MYBPC1 Antibody

MBS8514903-01mLAF610 0.1mL(AF610)
EUR 465

MYBPC1 Antibody

MBS8514903-01mLAF635 0.1mL(AF635)
EUR 465

MYBPC1 Antibody

MBS150745-01mg 0.1mg
EUR 445

MYBPC1 Antibody

MBS150745-5x01mg 5x0.1mg
EUR 1965

MYBPC1 Antibody

MBS150866-01mg 0.1mg
EUR 445

MYBPC1 Antibody

MBS150866-5x01mg 5x0.1mg
EUR 1965

MYBPC1 Antibody

MBS9605653-01mL 0.1mL
EUR 260

MYBPC1 Antibody

MBS9605653-02mL 0.2mL
EUR 305

MYBPC1 Antibody

MBS9605653-5x02mL 5x0.2mL
EUR 1220

MYBPC1 Antibody

MBS9506551-005mL 0.05mL
EUR 285

MYBPC1 Antibody

MBS9506551-01mL 0.1mL
EUR 385

MYBPC1 Antibody

MBS9506551-5x01mL 5x0.1mL
EUR 1590

MYBPC1 Antibody

C16778-100ul 100μl
EUR 217
Description: MYBPC1 Rabbit Polyclonal Antibody

MYBPC1 Antibody

C16778-50ul 50μl
EUR 143.5
Description: MYBPC1 Rabbit Polyclonal Antibody

Mast Cell-Degranulating Peptide (MCD Peptide) / Peptide 401

004-04 100 μg
EUR 140.4

MYBPC1 siRNA (Rat)

MBS8216708-15nmol 15nmol
EUR 405

MYBPC1 siRNA (Rat)

MBS8216708-30nmol 30nmol
EUR 565

MYBPC1 siRNA (Rat)

MBS8216708-5x30nmol 5x30nmol
EUR 2450

MYBPC1 Rabbit pAb

A8348-200ul 200 ul
EUR 550.8

MYBPC1 Rabbit pAb

A8348-20ul 20 ul
EUR 219.6

MYBPC1 Rabbit pAb

A8348 500μL
EUR 88.56

MYBPC1 siRNA (Human)

MBS8213156-15nmol 15nmol
EUR 405

MYBPC1 siRNA (Human)

MBS8213156-30nmol 30nmol
EUR 565

MYBPC1 siRNA (Human)

MBS8213156-5x30nmol 5x30nmol
EUR 2450

Mybpc1 (untagged) - Rat myosin binding protein C, slow type (Mybpc1)

RN217519 10 µg Ask for price

anti- MYBPC1 antibody

FNab05454 100µg
EUR 606.3
Description: Antibody raised against MYBPC1

MYBPC1 Antibody (Center)

MBS9207145-008mL 0.08mL
EUR 210

MYBPC1 Antibody (Center)

MBS9207145-04mL 0.4mL
EUR 430

MYBPC1 Antibody (Center)

MBS9207145-5x04mL 5x0.4mL
EUR 1910

Recombinant Human MYBPC1

MBS7614461-005mg 0.05mg
EUR 405

Recombinant Human MYBPC1

MBS7614461-02mg 0.2mg
EUR 760

Recombinant Human MYBPC1

MBS7614461-1mg 1mg
EUR 2175

Recombinant Human MYBPC1

MBS7614461-5x1mg 5x1mg
EUR 8410

MYBPC1 Polyclonal Antibody

ABP55302-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MYBPC1 from Human, Mouse, Rat. This MYBPC1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MYBPC1 at AA range: 190-270

MYBPC1 Polyclonal Antibody

ABP55302-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MYBPC1 from Human, Mouse, Rat. This MYBPC1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MYBPC1 at AA range: 190-270

MYBPC1 Polyclonal Antibody

ABP55302-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MYBPC1 from Human, Mouse, Rat. This MYBPC1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MYBPC1 at AA range: 190-270

MYBPC1 Polyclonal Antibody

E98348 100ul
EUR 225
Description: Available in various conjugation types.

MYBPC1 Polyclonal Antibody

E20-72926 100ug
EUR 225
Description: Available in various conjugation types.

Polyclonal MYBPC1 Antibody

AMM06515G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MYBPC1 . This antibody is tested and proven to work in the following applications:

Polyclonal MYBPC1 Antibody

AMM06516G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MYBPC1 . This antibody is tested and proven to work in the following applications:

MYBPC1 Conjugated Antibody

C34821 100ul
EUR 476.4

MYBPC1 Polyclonal Antibody

BT-AP05674-100ul 100ul Ask for price
Description: MYBPC1 encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

MYBPC1 Polyclonal Antibody

BT-AP05674-20ul 20ul Ask for price
Description: MYBPC1 encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

MYBPC1 Polyclonal Antibody

BT-AP05674-50ul 50ul Ask for price
Description: MYBPC1 encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

MYBPC1 Polyclonal Antibody

E44H02831 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

MYBPC1 Polyclonal Antibody

MBS9244402-01mL 0.1mL
EUR 415

MYBPC1 Polyclonal Antibody

MBS9244402-5x01mL 5x0.1mL
EUR 1841

MYBPC1 Polyclonal Antibody

MBS9128085-002mL 0.02mL
EUR 200

MYBPC1 Polyclonal Antibody

MBS9128085-005mL 0.05mL
EUR 255

MYBPC1 Polyclonal Antibody

MBS9128085-01mL 0.1mL
EUR 345

MYBPC1 Polyclonal Antibody

MBS9128085-02mL 0.2mL
EUR 545

MYBPC1 Polyclonal Antibody

MBS9128085-5x02mL 5x0.2mL
EUR 2265

MYBPC1 Polyclonal Antibody

MBS8573914-01mL 0.1mL
EUR 305

MYBPC1 Polyclonal Antibody

MBS8573914-01mLAF405L 0.1mL(AF405L)
EUR 565

MYBPC1 Polyclonal Antibody

MBS8573914-01mLAF405S 0.1mL(AF405S)
EUR 565

MYBPC1 Polyclonal Antibody

MBS8573914-01mLAF610 0.1mL(AF610)
EUR 565

MYBPC1 Polyclonal Antibody

MBS8573914-01mLAF635 0.1mL(AF635)
EUR 565

MYBPC1 Polyclonal Antibody

MBS8523907-01mg 0.1mg
EUR 305

MYBPC1 Polyclonal Antibody

MBS8523907-01mLAF405L 0.1mL(AF405L)
EUR 465

MYBPC1 Polyclonal Antibody

MBS8523907-01mLAF405S 0.1mL(AF405S)
EUR 465

MYBPC1 Polyclonal Antibody

MBS8523907-01mLAF610 0.1mL(AF610)
EUR 465

MYBPC1 Polyclonal Antibody

MBS8523907-01mLAF635 0.1mL(AF635)
EUR 465

MYBPC1 Polyclonal Antibody

MBS2536427-002mL 0.02mL
EUR 140

MYBPC1 Polyclonal Antibody

MBS2536427-006mL 0.06mL
EUR 180

MYBPC1 Polyclonal Antibody

MBS2536427-012mL 0.12mL
EUR 260

MYBPC1 Polyclonal Antibody

MBS2536427-02mL 0.2mL
EUR 405

MYBPC1 Conjugated Antibody

MBS9445566-01mLAF350 0.1mL(AF350)
EUR 480

MYBPC1 Conjugated Antibody

MBS9445566-01mLAF405 0.1mL(AF405)
EUR 480

MYBPC1 Conjugated Antibody

MBS9445566-01mLAF488 0.1mL(AF488)
EUR 480

MYBPC1 Conjugated Antibody

MBS9445566-01mLAF555 0.1mL(AF555)
EUR 480

MYBPC1 Conjugated Antibody

MBS9445566-01mLBiotin 0.1mL(Biotin)
EUR 480

Peptide T

057-01 5 mg
EUR 140.4

FGL Peptide

073-36 100 μg
EUR 214.92

APK peptide

076-81 200 μg
EUR 199.8

NEF peptide

076-83 500 μg
EUR 140.4

SHA peptide

076-84 500 μg
EUR 177.12

YSY peptide

076-86 100 μg
EUR 230.04

Rat Mybpc1 ELISA Kit

ELI-44010r 96tests
EUR 756

Peptide E / 3200-Dalton Adrenal Enkephalin-Containing Peptide (Bovine)

024-57 200 μg
EUR 86.4

PSTAIR Peptide

070-61 500 μg
EUR 129.6

PGMtide Peptide

040-69 100 μg
EUR 316.44

Adjuvant Peptide

070-05 500 μg
EUR 36.72

Human MYBPC1 ELISA KIT

EF001013 96tests
EUR 566

Peptide-epsilon

058-22 500 μg
EUR 114.48

Statherin-derived peptide protects in opposition to intrinsic erosion

Targets: Within the current research, we used an in vitro preliminary intrinsic erosion mannequin to judge: (experiment 1) the affect of the diploma of serine (Ser) phosphorylation of peptides containing the 15 N-terminal residues of statherin and (experiment 2) the impact of various concentrations of the peptide with one of the best efficiency in experiment 1 on preliminary enamel erosion.

Design: Bovine enamel specimens had been divided into 6 teams (n = 15/group) for every experiment. In experiment 1, the peptides evaluated (at 1.88 × 10-5 M) had been: not phosphorylated (StatSS), phosphorylated in Ser2 (StatpSS), phosphorylated in Ser3 (StatSpS) phosphorylated in Ser2 and Ser3 (StatpSpS).

Phosphate buffer and human recombinant statherin had been used as destructive and optimistic controls, respectively. In experiment 2, StatpSpS was evaluated at completely different concentrations: 0.94, 1.88, 3.76 and seven.52 × 10-5 M. Phosphate buffer and 0.1 mg/mL CaneCPI-5 had been employed as destructive and optimistic controls, respectively. In every experiment, the specimens had been incubated with the options for two h, then the AEP was allowed to kind (underneath human pooled saliva) for two h. The specimens had been then challenged with 0.01 M HCl for 10 s. Demineralization was evaluated by share of floor hardness change (%SHC). Knowledge had been analyzed by ANOVA and Tukey’s take a look at (p < 0.05).

Outcomes: In experiment 1, solely StatpSpS considerably decreased the % SHC as compared with management. In experiment 2, 1.88 × 10-5 M StatpSpS considerably decreased the %SHC as compared with management.

The Usefulness of Diagnostic Panels Based mostly on Circulating Adipocytokines/Regulatory Peptides, Renal Perform Assessments, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Prognosis and Prognosis of Sort 2 Diabetes Mellitus with Weight problems

The quantitative evaluation of chosen regulatory molecules, i.e., adropin, irisin, and vaspin within the plasma of overweight sufferers with newly recognized, untreated sort 2 diabetes mellitus, and in the identical sufferers after six months of utilizing metformin, in relation to adropinemia, irisinemia and vaspinemia in overweight people, was carried out. The connection between plasma focus of the adipocytokines/regulatory peptides and parameters of renal operate (albumin/creatinine ratio-ACR, estimated glomerular filtration rate-eGFR), values of insulin resistance indicators (Homeostatic Mannequin Evaluation of Insulin Resistance (HOMA-IR2), Homeostatic Mannequin Evaluation of Insulin Sensitivity (HOMA-S), Homeostatic Mannequin Evaluation of β-cell operate (HOMA-B), quantitative insulin sensitivity verify index (QUICKI), insulin), and parameters of carbohydrate-lipid metabolism (fasting plasma glucose-FPG, glycated hemoglobin-HbA1C, estimated glucose disposal rate-eGDR, fasting lipid profile, TG/HDL ratio) in overweight sort 2 diabetic sufferers was additionally investigated. Circulating irisin and vaspin had been discovered considerably completely different in topics with metabolically wholesome weight problems and in sort 2 diabetic sufferers.

Vital will increase in blood ranges of each analyzed adipokines/regulatory peptides had been noticed in diabetic sufferers after six months of metformin remedy, as in comparison with pre-treatment ranges. The change in plasma vaspin stage in response to metformin remedy was parallel with the bettering of insulin resistance/sensitivity parameters. An try was made to establish a set of biochemical exams that will differ enormously in overweight non-diabetic topics and overweight sufferers with sort 2 diabetes, in addition to a set of parameters which are altering in sufferers with sort 2 diabetes underneath the affect of six months metformin remedy, and thus differentiating sufferers’ metabolic state earlier than and after remedy.

 For these information analyses, each statistical measures of energy of the relationships of particular person parameters, in addition to multidimensional strategies, together with discriminant evaluation and multifactorial evaluation derived from machine studying strategies, had been used. Adropin, irisin, and vaspin had been discovered as promising regulatory molecules, which can become helpful indicators within the early detection of T2DM and differentiating the weight problems phenotype with regular metabolic profile from T2DM overweight sufferers. Multifactorial discriminant evaluation revealed that irisin and vaspin plasma ranges contribute clinically related data in regards to the effectiveness of metformin remedy in T2D sufferers.

 Among the many units of variables differentiating with the best accuracy the metabolic state of sufferers earlier than and after six-month metformin remedy, had been: (1) vaspin, HbA1c, HDL, LDL, TG, insulin, and HOMA-B (ACC = 88 [%]); (2) vaspin, irisin, QUICKI, and eGDR (ACC = 86 [%]); in addition to, (3) vaspin, irisin, LDL, HOMA-S, ACR, and eGFR (ACC = 86 [%]).

Nop30 Blocking Peptide

MBS823317-1mg 1mg
EUR 190

Nop30 Blocking Peptide

MBS823317-5mg 5mg
EUR 345

Nop30 Blocking Peptide

MBS823317-5x5mg 5x5mg
EUR 1465

Mast Cell-Degranulating Peptide (MCD Peptide) / Peptide 401

004-04 100 μg
EUR 140.4

Peptide T

057-01 5 mg
EUR 140.4

FGL Peptide

073-36 100 μg
EUR 214.92

APK peptide

076-81 200 μg
EUR 199.8

NEF peptide

076-83 500 μg
EUR 140.4

SHA peptide

076-84 500 μg
EUR 177.12

YSY peptide

076-86 100 μg
EUR 230.04

Peptide E / 3200-Dalton Adrenal Enkephalin-Containing Peptide (Bovine)

024-57 200 μg
EUR 86.4

PSTAIR Peptide

070-61 500 μg
EUR 129.6

PGMtide Peptide

040-69 100 μg
EUR 316.44

Adjuvant Peptide

070-05 500 μg
EUR 36.72

Peptide-epsilon

058-22 500 μg
EUR 114.48

Delicious Peptide

070-21 5 mg
EUR 160.92

proSex peptide (20-55)

040-30 100 μg
EUR 355.32

proSex peptide (28-55)

040-31 100 μg
EUR 282.96

proSex peptide (40-55)

040-32 100 μg
EUR 214.92

Bombinin-Like Peptide 1 amide / prepro-Bombinin-Like Peptide (44-70) amide / prepro-Bombinin-Like Peptide (107-133) amide

007-60 100 μg
EUR 214.92

Peptide F-9

038-06 200 μg
EUR 58.32

Sturgeon Peptide (137-158)

021-94 100 μg
EUR 177.12

Peptide Lv (Rat)

008-73 100 μg
EUR 469.8

NGR Peptide 1

025-74 200 μg
EUR 184.68

Anorexigenic Peptide

070-10 5 mg
EUR 86.4

GnRH Associated Peptide (GAP) (1-13) / GnRH Precursor Peptide (14-26) (Human)

029-03 500 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-24) / GnRH Precursor Peptide (14-37) (Human)

029-04 100 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-53) / GnRH Precursor Peptide (14-66) (Human)

029-05 20 μg
EUR 267.84

GnRH Associated Peptide (GAP) (25-53) / GnRH Precursor Peptide (38-66) (Human)

029-06 100 μg
EUR 114.48

Bid BH3 peptide

025-87 1 mg
EUR 170.64

AF-16 Peptide

033-44 200 μg
EUR 214.92

Peptide Lv (Human)

008-71 100 μg
EUR 405

Peptide Lv (Mouse)

008-72 100 μg
EUR 469.8

GnRH Associated Peptide (GAP) (1-13) / Gn-RH Precursor Peptide (14-26) (Rat)

029-08 200 μg
EUR 64.8

Peptide B (Bovine)

024-56 200 μg
EUR 81

Peptide F (Bovine)

024-58 200 μg
EUR 114.48

ExE peptide M3mP6

064-33 200 μg
EUR 244.08

PLP Peptide (103-116) (Bovine)

070-14 5 mg
EUR 140.4

NOP5/NOP58 Blocking Peptide

33R-5398 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NOP5/NOP58 antibody, catalog no. 70R-3412

FMRF-Like Peptide

047-32 1 mg
EUR 27

Joining Peptide (Rat)

047-91 200 μg
EUR 160.92

Growth Hormone-Releasing Peptide-Related Peptide-1 (fGRP-RP-1) (Frog)

048-80 500 μg
EUR 177.12

Growth Hormone-Releasing Peptide-Related Peptide-2 (fGRP-RP-2) (Frog)

048-81 200 μg
EUR 214.92

Growth Hormone-Releasing Peptide-Related Peptide-3 (fGRP-RP-3) (Frog)

048-82 200 μg
EUR 214.92

Peptide T (4-8)

057-04 500 μg
EUR 64.8

Peptide T (5-8)

057-05 500 μg
EUR 64.8

Vasonatrin Peptide (VNP)

005-47 200 μg
EUR 214.92

Opioid Peptide Library

L-002 58 peptides
EUR 2691.36

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine)

064-01 200 μg
EUR 108

NOP58 Blocking Peptide

DF13192-BP 1mg
EUR 234

NOP56 Blocking Peptide

MBS8247999-1mg 1mg
EUR 190

NOP56 Blocking Peptide

MBS8247999-5mg 5mg
EUR 345

NOP56 Blocking Peptide

MBS8247999-5x5mg 5x5mg
EUR 1465

NOP58 Blocking Peptide

MBS9621895-1mg 1mg
EUR 380

NOP58 Blocking Peptide

MBS9621895-5x1mg 5x1mg
EUR 1650

NOP10 Blocking Peptide

MBS9622423-1mg 1mg
EUR 380

NOP10 Blocking Peptide

MBS9622423-5x1mg 5x1mg
EUR 1650

Heparin Binding Peptide

025-47 500 μg
EUR 102.6

Gastrin Related Peptide

027-09 5 mg
EUR 73.44

PGMtide Control Peptide

040-70 100 μg
EUR 316.44

Growth Blocking Peptide

046-92 100 μg
EUR 255.96

Neuron Specific Peptide

047-55 200 μg
EUR 140.4

Obesity Peptide Library

L-003 160 peptides
EUR 7267.32

[D-Ala1]-Peptide T

057-02 5 mg
EUR 282.96

Peptide YY (PYY) (Human)

059-01 200 μg
EUR 119.88

Eledoisin Related Peptide

046-04 5 mg
EUR 58.32

proSex peptide (28-55) - EIA Kit

EK-040-31 96 wells
EUR 603.72

Peptide F 1 (Lobster)

047-62 500 μg
EUR 73.44

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human)

064-07 200 μg
EUR 114.48

Morphine Tolerance Peptide

050-13 1 mg
EUR 102.6

Phosphate Acceptor Peptide

058-24 500 μg
EUR 73.44

Peptide I / pro-Histine-Rich Basic Peptide (HRBP) (1-26) (Aplysia brasiliana)

047-39 200 μg
EUR 444.96

Peptide II / pro-Histine-Rich Basic Peptide (HRBP) (29-40) (Aplysia brasiliana)

047-40 500 μg
EUR 214.92

Peptide I / pro-Histine-Rich Basic Peptide (HRBP) (1-26) (Aplysia californica)

047-42 200 μg
EUR 444.96

Peptide II / pro-Histine-Rich Basic Peptide (HRBP) (29-40) (Aplysia californica)

047-43 500 μg
EUR 214.92

Nop30 Antibody

20-abx141839
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  • 100 ul
  • 200 ul
  • 50 ul

Nop30 Antibody

20-abx008470
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  • 100 ul
  • 200 ul
  • 30 ul

Nop30 Antibody

24090 100ul
EUR 479

Nop30 Antibody

24090-100ul 100ul
EUR 468

Nop30 Antibody

2225-002mg 0.02 mg
EUR 206.18
Description: Nop30 Antibody: Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and the caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. An alternate splicing isoform of ARC was identified as Nop30. While ARC interacts with caspase-2 and -8 and suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3, Nop30 multimerizes and binds to the splicing factor SRp30c and may act to influence alternative splice site selection in vivo. The Nop30 antibody will not detect ARC protein.

Nop30 Antibody

2225-01mg 0.1 mg
EUR 523.7
Description: Nop30 Antibody: Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and the caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. An alternate splicing isoform of ARC was identified as Nop30. While ARC interacts with caspase-2 and -8 and suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3, Nop30 multimerizes and binds to the splicing factor SRp30c and may act to influence alternative splice site selection in vivo. The Nop30 antibody will not detect ARC protein.

Nop30 Antibody

E38PA2340 100ul
EUR 225
Description: Available in various conjugation types.

Nop30 antibody

70R-50659 100 ul
EUR 242
Description: Purified Polyclonal Nop30 antibody

Nop30 Antibody

MBS9411181-01mL 0.1mL
EUR 495

Nop30 Antibody

MBS9411181-5x01mL 5x0.1mL
EUR 2075

Nop30 Antibody

MBS8581240-01mL 0.1mL
EUR 305

Nop30 Antibody

MBS8581240-01mLAF405L 0.1mL(AF405L)
EUR 465

Nop30 Antibody

MBS8581240-01mLAF405S 0.1mL(AF405S)
EUR 465

Nop30 Antibody

MBS8581240-01mLAF610 0.1mL(AF610)
EUR 465

Nop30 Antibody

MBS8581240-01mLAF635 0.1mL(AF635)
EUR 465

Nop30 Antibody

MBS151174-01mg 0.1mg
EUR 445

Nop30 Antibody

MBS151174-5x01mg 5x0.1mg
EUR 1965

Nop30 Antibody

MBS5315278-01mL 0.1mL
EUR 470

Nop30 Antibody

MBS5315278-5x01mL 5x0.1mL
EUR 1955

FGL Peptide - Cy3 Labeled

FC3-073-36 1 nmol
EUR 672.84

FGL Peptide - Cy5 Labeled

FC5-073-36 1 nmol
EUR 756

FGL Peptide - FAM Labeled

FG-073-36A 1 nmol
EUR 405

Pedal Peptide (Pep) (Aplysia)

047-61 500 μg
EUR 177.12

ExE peptide M3mP6 mutant

064-35 200ug
EUR 234.36

ExE peptide M3mP6 mutant

064-37 200ug
EUR 234.36

FGL Peptide - FITC Labeled

FG-073-36B 1 nmol
EUR 405

AF-16 Peptide - Antibody

H-033-44 100 μl
EUR 336.96

Schizophrenia Related Peptide

047-79 5 mg
EUR 44.28

Insulin B (22-25) Peptide

035-08 5 mg
EUR 86.4

Eosinophilotactic Peptide (AGSE)

070-28 5 mg
EUR 27

Eosinophilotactic Peptide (VGSE)

070-29 5 mg
EUR 27

Cell Penetrating ARF Peptide (26-44)

068-56 500 μg
EUR 640.44

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine) - RIA Kit

RK-064-01 125 tubes
EUR 932.04

FGL Peptide - Biotin Labeled

B-073-36 20 μg
EUR 405

Peptide F (Bovine) - Antibody

H-024-58 50 μl
EUR 238.68

Brain Peptide (Bees) Library

L-007 51 peptides
EUR 6456.24

AAP40644-100UG - NOP56 Peptide

AAP40644-100UG 100ug
EUR 99

AAP40645-100UG - NOP56 Peptide

AAP40645-100UG 100ug
EUR 99

Gastrointestinal Peptide Library

L-006 200 peptides
EUR 7267.32

[D-Arg14, D-Arg15]-MGF Peptide amide / C-terminal peptide of IGF-1 Ec amide

033-34 100 μg
EUR 177.12

Peptide R / CXCR4 Antagonist

030-25 200 μg
EUR 203.04

PGMtide Peptide - Cy3 Labeled

FC3-040-69 1 nmol
EUR 925.56

PGMtide Peptide - FAM Labeled

FG-040-69A 5 nmol
EUR 537.84

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human) - Antibody

H-064-07 50 μl
EUR 238.68

[D-Ala1]-Peptide T amide

057-03 500 μg
EUR 140.4

Peptide F (Bovine) - RIA Kit

RK-024-58 125 tubes
EUR 932.04

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human) - RIA Kit

RK-064-07 125 tubes
EUR 932.04

Catch-Relaxing Peptide (CARP)

047-20 1 mg
EUR 199.8

Calmodulin Binding Peptide 1

070-17 20 μg
EUR 214.92

FGL Peptide - Rhodamine Labeled

FR-073-36 1 nmol
EUR 537.84

Peptide-Depleted Plasma (Rat)

MB-099-02 2 ml
EUR 119.88

Glycogenolysis-Inhibiting Peptide

023-63 500 μg
EUR 177.12

Anti-Inflammatory Peptide 1

004-01 200 μg
EUR 27

Anti-Inflammatory Peptide 2

004-02 200 μg
EUR 27

Anti-Inflammatory Peptide 3

004-03 200 μg
EUR 27

Urokinase-Derived Peptide A6

025-12 500 μg
EUR 129.6

PGMtide Peptide - Biotin Labeled

B-040-69 20 μg
EUR 537.84

Peptide 34 / GPR-54 Agonist

048-94 200 μg
EUR 114.48

FGL Peptide - I-125 Labeled

T-073-36 10 μCi
EUR 1145.88

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human) - FAM Labeled

FG-064-07A 1 nmol
EUR 336.96

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine) - I-125 Labeled

T-064-01 10 μCi
EUR 1145.88

Peptide-Depleted Plasma (Human)

MB-099-01 2 ml
EUR 119.88

F3 Peptide / HMGN2 Fragment 3

004-12 100 μg
EUR 214.92

Antimicrobial Trp-rich peptide

004-05 100 μg
EUR 140.4

Fibronectin CS1 Peptide (EILDVPST)

025-20 500 μg
EUR 86.4

Myosin Kinase Inhibiting Peptide

058-20 500 μg
EUR 50.76

Peptide YY (PYY) (3-36) (Human)

059-02 200 μg
EUR 102.6

PGMtide Peptide - Rhodamine Labeled

FR-040-69 5 nmol
EUR 604.8

Anti-Angiogenic Peptide Library

L-008A 88 peptides
EUR 6067.44

Peptide YY (PYY) (Human) - Antibody

H-059-01 100 μl
EUR 469.8

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine) - Purified IgG Antibody

G-064-01 400 μg
EUR 438.48

NOP53 Peptide - C-terminal region

MBS3241602-01mg 0.1mg
EUR 180

NOP53 Peptide - C-terminal region

MBS3241602-5x01mg 5x0.1mg
EUR 730

NOP14 Peptide - N-terminal region

MBS3244806-01mg 0.1mg
EUR 180

NOP14 Peptide - N-terminal region

MBS3244806-5x01mg 5x0.1mg
EUR 730

NOP14 Peptide - N-terminal region

MBS3244807-01mg 0.1mg
EUR 180

NOP14 Peptide - N-terminal region

MBS3244807-5x01mg 5x0.1mg
EUR 730

NOP56 Peptide - C-terminal region

MBS3244838-01mg 0.1mg
EUR 180

NOP56 Peptide - C-terminal region

MBS3244838-5x01mg 5x0.1mg
EUR 730

NOP56 Peptide - C-terminal region

MBS3244839-01mg 0.1mg
EUR 180

NOP56 Peptide - C-terminal region

MBS3244839-5x01mg 5x0.1mg
EUR 730

Peptide A / p60v-src (137-157)

058-21 500 μg
EUR 135

pro-Opionmelanocortin / J Peptide

022-22 200 μg
EUR 177.12

Cancer-Targeting Peptide Library

L-015 289 peptides
EUR 7253.28

C28 optimized peptide 6 (Human)

073-82 100 μg
EUR 235.44

NOP5 Peptide - middle region

MBS3237938-01mg 0.1mg
EUR 180

NOP5 Peptide - middle region

MBS3237938-5x01mg 5x0.1mg
EUR 730

Kemptide / Phosphate Acceptor Peptide

058-16 500 μg
EUR 36.72

Bioactive Secretory Peptide Library

L-009 1016 peptides
EUR 31350.24

Peptide YY (PYY) (Human) - EIA Kit

EK-059-01 96 wells
EUR 617.76