juli 20, 2024
lotuskringpoeldijk

Mitochondrial-Focused Peptide, SS31, Protects Murine 661W Cells from Oxidative Harm by way of Induction

Synthesis and Biochemical Analysis of Samarium-153 Oxide Nanoparticles Functionalized with iPSMA-Bombesin Heterodimeric Peptide 

Developments within the design of lanthanide oxide nanoparticles (NPs) have unleashed all kinds of biomedical purposes. A number of varieties of hepatic most cancers cells overexpress two proteins: the gastrin-releasing peptide receptor (GRPr), which particularly acknowledges the bombesin (BN) peptide, and the prostate-specific membrane antigen (PSMA), which particularly binds to a number of peptides that inhibit its exercise (iPSMA).

This analysis synthesized and physicochemically characterised Sm₂O₃ nanoparticles functionalized with the iPSMA-BN heterodimeric peptide and studied the consequences on their structural, biochemical and preclinical properties after activation by neutron irradiation for doable use in molecular dual-targeted radiotherapy of hepatocellular carcinoma.

The Sm₂O₃ NPs had been synthesized by the precipitation-calcination technique and functionalized with iPSMA-BN peptide utilizing the DOTA macrocycle as a linking agent. Evaluation of physicochemical characterization by way of TEM, EDS, XRD, UV-Vis, FT-IR, DSL, and zeta potential outcomes confirmed the formation of Sm₂O₃-iPSMA-BN NPs (94.23 ± 5.98 nm), and their physicochemical properties weren’t affected after neutron activation.

The nanosystem confirmed a excessive affinity with respect to PSMA and GRPr in HepG2 cells ( Okd = 6.6 ± 1.6 nM) and GRPr in PC3 cells ( Okd = 10.6 ± 1.9 nM). 153Sm₂O₃-iPSMA-BN NPs exhibited radioluminescent properties, making doable in vivo optical imaging of their biodistribution in mice. The outcomes obtained from this analysis help additional preclinical research designed to judge the dosimetry and therapeutic efficacy of 153Sm₂O₃-iPSMA-BN nanoparticles for in vivo imaging and molecular dual-targeted radiotherapy of liver tumors overexpressing PSMA and/or GRPr proteins.

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PTCHD1 Peptide

42-686P 0.1 mg
EUR 405.6
Description: (IN) PTCHD1 Peptide

PTCHD1 Immunizing Peptide

MBS427529-01mg 0.1mg
EUR 225

PTCHD3 Immunizing Peptide

MBS427798-01mg 0.1mg
EUR 225

PTCHD2 siRNA

20-abx930257
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

PTCHD2 Antibody

6637-002mg 0.02 mg
EUR 206.18
Description: PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.

PTCHD2 Antibody

6637-01mg 0.1 mg
EUR 523.7
Description: PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.

PTCHD2 Antibody

24792 100ul
EUR 479

PTCHD2 Antibody

24792-100ul 100ul
EUR 468

PTCHD2 Antibody

24797 100ul
EUR 479

PTCHD2 Antibody

24797-100ul 100ul
EUR 468

PTCHD2 Antibody

25404 100ul
EUR 479

PTCHD2 Antibody

25404-100ul 100ul
EUR 468

PTCHD2 Antibody

4915-002mg 0.02 mg
EUR 206.18
Description: PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.

PTCHD2 Antibody

4915-01mg 0.1 mg
EUR 523.7
Description: PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.

PTCHD2 Antibody

4925-002mg 0.02 mg
EUR 206.18
Description: PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.

PTCHD2 Antibody

4925-01mg 0.1 mg
EUR 523.7
Description: PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.

PTCHD2 Antibody

MBS9408772-01mL 0.1mL
EUR 495

PTCHD2 Antibody

MBS9408772-5x01mL 5x0.1mL
EUR 2075

PTCHD2 Antibody

MBS9410982-01mL 0.1mL
EUR 495

PTCHD2 Antibody

MBS9410982-5x01mL 5x0.1mL
EUR 2075

PTCHD2 Antibody

MBS9407915-01mL 0.1mL
EUR 495

PTCHD2 Antibody

MBS9407915-5x01mL 5x0.1mL
EUR 2075

PTCHD2 Antibody

MBS151200-01mg 0.1mg
EUR 445

PTCHD2 Antibody

MBS151200-5x01mg 5x0.1mg
EUR 1965

PTCHD2 Antibody

MBS151575-01mg 0.1mg
EUR 445

PTCHD2 Antibody

MBS151575-5x01mg 5x0.1mg
EUR 1965

PTCHD2 Antibody

MBS151579-01mg 0.1mg
EUR 445

PTCHD2 Antibody

MBS151579-5x01mg 5x0.1mg
EUR 1965

PTCHD2 (untagged)-Human patched domain containing 2 (PTCHD2)

SC316598 10 µg Ask for price

PTCHD2 (GFP-tagged) - Human patched domain containing 2 (PTCHD2)

RG211355 10 µg Ask for price

Ptchd2 (untagged) - Mouse patched domain containing 2 (Ptchd2), (10ug)

MC224316 10 µg Ask for price

PTCHD2 siRNA (Human)

MBS8237840-15nmol 15nmol
EUR 405

PTCHD2 siRNA (Human)

MBS8237840-30nmol 30nmol
EUR 565

PTCHD2 siRNA (Human)

MBS8237840-5x30nmol 5x30nmol
EUR 2450

PTCHD1 Antibody (Center) Blocking peptide

MBS9218358-INQUIRE INQUIRE Ask for price

PTCHD3 Antibody (C-term) Blocking peptide

MBS9218367-INQUIRE INQUIRE Ask for price

Ptchd2 (GFP-tagged) - Mouse patched domain containing 2 (Ptchd2), (10ug)

MG223294 10 µg Ask for price

Ptchd2 (Myc-DDK-tagged) - Mouse patched domain containing 2 (Ptchd2)

MR223294 10 µg Ask for price

PTCHD2 (Myc-DDK-tagged)-Human patched domain containing 2 (PTCHD2)

RC211355 10 µg Ask for price

Polyclonal PTCHD2 Antibody

AMR09590G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PTCHD2 . This antibody is tested and proven to work in the following applications:

Polyclonal PTCHD2 Antibody

AMR09591G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PTCHD2 . This antibody is tested and proven to work in the following applications:

Polyclonal PTCHD2 Antibody

AMR09592G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PTCHD2 . This antibody is tested and proven to work in the following applications:

PTCHD2 Polyclonal Antibody

MBS9234398-01mL 0.1mL
EUR 415

PTCHD2 Polyclonal Antibody

MBS9234398-5x01mL 5x0.1mL
EUR 1841

Human PTCHD2 shRNA Plasmid

20-abx961520
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Lenti ORF clone of Ptchd2 (mGFP-tagged) - Mouse patched domain containing 2 (Ptchd2)

MR223294L4 10 µg Ask for price

Rabbit Polyclonal PTCHD2 Antibody

TA319981 100 µg Ask for price

Rabbit Polyclonal PTCHD2 Antibody

TA319982 100 µg Ask for price

Rabbit Polyclonal PTCHD2 Antibody

TA319983 100 µg Ask for price

AAP94899-100UG - Ptchd3 Blocking peptide (N terminal region)

AAP94899-100UG 100ug
EUR 99

PTCHD2 ORF Vector (Human) (pORF)

ORF028512 1.0 ug DNA Ask for price

Ptchd2 ORF Vector (Mouse) (pORF)

ORF055152 1.0 ug DNA
EUR 1886.4

Lenti ORF clone of Ptchd2 (Myc-DDK-tagged) - Mouse patched domain containing 2 (Ptchd2)

MR223294L3 10 µg Ask for price

Human PTCHD2 knockout cell line

ABC-KH12357 1 vial Ask for price
Description: Human PTCHD2 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human PTCHD2 knockdown cell line

ABC-KD12357 1 vial Ask for price
Description: Human PTCHD2 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Mast Cell-Degranulating Peptide (MCD Peptide) / Peptide 401

004-04 100 μg
EUR 140.4

Polyclonal PTCHD2 Antibody (N-Terminus)

AMR09593G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PTCHD2 (N-Terminus). This antibody is tested and proven to work in the following applications:

Lenti ORF particles, Ptchd2 (GFP-tagged) - Mouse patched domain containing 2 (Ptchd2), 200ul, >10^7 TU/mL

MR223294L4V 200 µl Ask for price

Lenti ORF particles, PTCHD2 (mGFP-tagged) - Human patched domain containing 2 (PTCHD2), 200ul, >10^7 TU/mL

RC211355L2V 200 µl Ask for price

Lenti ORF particles, PTCHD2 (mGFP-tagged) - Human patched domain containing 2 (PTCHD2), 200ul, >10^7 TU/mL

RC211355L4V 200 µl Ask for price

Lenti ORF particles, PTCHD2 (Myc-DDK tagged) - Human patched domain containing 2 (PTCHD2), 200ul, >10^7 TU/mL

RC211355L1V 200 µl Ask for price

Lenti ORF particles, PTCHD2 (Myc-DDK tagged) - Human patched domain containing 2 (PTCHD2), 200ul, >10^7 TU/mL

RC211355L3V 200 µl Ask for price

Lenti ORF particles, Ptchd2 (Myc-DDK-tagged) - Mouse patched domain containing 2 (Ptchd2), 200ul, >10^7 TU/mL

MR223294L3V 200 µl Ask for price

Ptchd2 3'UTR GFP Stable Cell Line

TU167223 1.0 ml Ask for price

PTCHD2 3'UTR GFP Stable Cell Line

TU069132 1.0 ml
EUR 1672.8

PTCHD2 sgRNA CRISPR Lentivector set (Human)

K1748901 3 x 1.0 ug
EUR 406.8

Ptchd2 sgRNA CRISPR Lentivector set (Mouse)

K3185201 3 x 1.0 ug
EUR 406.8

OAPB01435-100UG - PTCHD2 Antibody - C-terminal

OAPB01435-100UG 100ug
EUR 389

OAPB01436-100UG - PTCHD2 Antibody - N-terminal

OAPB01436-100UG 100ug
EUR 389

OAPB01521-100UG - PTCHD2 Antibody - N-terminal

OAPB01521-100UG 100ug
EUR 389

PTCHD2 Protein Vector (Human) (pPM-C-HA)

PV114048 500 ng Ask for price

PTCHD2 Protein Vector (Mouse) (pPM-C-HA)

PV220608 500 ng
EUR 2766

PTCHD2 3'UTR Luciferase Stable Cell Line

TU019132 1.0 ml
EUR 1672.8

Ptchd2 3'UTR Luciferase Stable Cell Line

TU117223 1.0 ml Ask for price

PTCHD2 Protein Vector (Human) (pPB-C-His)

PV114046 500 ng Ask for price

PTCHD2 Protein Vector (Human) (pPB-N-His)

PV114047 500 ng Ask for price

PTCHD2 Protein Vector (Human) (pPM-C-His)

PV114049 500 ng Ask for price

PTCHD2 Protein Vector (Mouse) (pPB-C-His)

PV220606 500 ng
EUR 2766

PTCHD2 Protein Vector (Mouse) (pPB-N-His)

PV220607 500 ng
EUR 2766

PTCHD2 Protein Vector (Mouse) (pPM-C-His)

PV220609 500 ng
EUR 2766

Peptide T

057-01 5 mg
EUR 140.4

FGL Peptide

073-36 100 μg
EUR 214.92

APK peptide

076-81 200 μg
EUR 199.8

NEF peptide

076-83 500 μg
EUR 140.4

SHA peptide

076-84 500 μg
EUR 177.12

YSY peptide

076-86 100 μg
EUR 230.04

Peptide E / 3200-Dalton Adrenal Enkephalin-Containing Peptide (Bovine)

024-57 200 μg
EUR 86.4

PSTAIR Peptide

070-61 500 μg
EUR 129.6

PGMtide Peptide

040-69 100 μg
EUR 316.44

Adjuvant Peptide

070-05 500 μg
EUR 36.72

PTCHD2 sgRNA CRISPR Lentivector (Human) (Target 1)

K1748902 1.0 ug DNA
EUR 184.8

PTCHD2 sgRNA CRISPR Lentivector (Human) (Target 2)

K1748903 1.0 ug DNA
EUR 184.8

PTCHD2 sgRNA CRISPR Lentivector (Human) (Target 3)

K1748904 1.0 ug DNA
EUR 184.8

Ptchd2 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3185203 1.0 ug DNA
EUR 184.8

Ptchd2 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3185204 1.0 ug DNA
EUR 184.8

Ptchd2 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3185202 1.0 ug DNA
EUR 184.8

Peptide-epsilon

058-22 500 μg
EUR 114.48

Delicious Peptide

070-21 5 mg
EUR 160.92

proSex peptide (20-55)

040-30 100 μg
EUR 355.32

proSex peptide (28-55)

040-31 100 μg
EUR 282.96

proSex peptide (40-55)

040-32 100 μg
EUR 214.92

Bombinin-Like Peptide 1 amide / prepro-Bombinin-Like Peptide (44-70) amide / prepro-Bombinin-Like Peptide (107-133) amide

007-60 100 μg
EUR 214.92

Peptide F-9

038-06 200 μg
EUR 58.32

Sturgeon Peptide (137-158)

021-94 100 μg
EUR 177.12

Peptide Lv (Rat)

008-73 100 μg
EUR 469.8

NGR Peptide 1

025-74 200 μg
EUR 184.68

Anorexigenic Peptide

070-10 5 mg
EUR 86.4

GnRH Associated Peptide (GAP) (1-13) / GnRH Precursor Peptide (14-26) (Human)

029-03 500 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-24) / GnRH Precursor Peptide (14-37) (Human)

029-04 100 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-53) / GnRH Precursor Peptide (14-66) (Human)

029-05 20 μg
EUR 267.84

GnRH Associated Peptide (GAP) (25-53) / GnRH Precursor Peptide (38-66) (Human)

029-06 100 μg
EUR 114.48

Bid BH3 peptide

025-87 1 mg
EUR 170.64

AF-16 Peptide

033-44 200 μg
EUR 214.92

Peptide Lv (Human)

008-71 100 μg
EUR 405

Peptide Lv (Mouse)

008-72 100 μg
EUR 469.8

GnRH Associated Peptide (GAP) (1-13) / Gn-RH Precursor Peptide (14-26) (Rat)

029-08 200 μg
EUR 64.8

Peptide B (Bovine)

024-56 200 μg
EUR 81

Peptide F (Bovine)

024-58 200 μg
EUR 114.48

ExE peptide M3mP6

064-33 200 μg
EUR 244.08

PLP Peptide (103-116) (Bovine)

070-14 5 mg
EUR 140.4

FMRF-Like Peptide

047-32 1 mg
EUR 27

Joining Peptide (Rat)

047-91 200 μg
EUR 160.92

Growth Hormone-Releasing Peptide-Related Peptide-1 (fGRP-RP-1) (Frog)

048-80 500 μg
EUR 177.12

Growth Hormone-Releasing Peptide-Related Peptide-2 (fGRP-RP-2) (Frog)

048-81 200 μg
EUR 214.92

Growth Hormone-Releasing Peptide-Related Peptide-3 (fGRP-RP-3) (Frog)

048-82 200 μg
EUR 214.92

Peptide T (4-8)

057-04 500 μg
EUR 64.8

Peptide T (5-8)

057-05 500 μg
EUR 64.8

Vasonatrin Peptide (VNP)

005-47 200 μg
EUR 214.92

Opioid Peptide Library

L-002 58 peptides
EUR 2691.36

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine)

064-01 200 μg
EUR 108

Heparin Binding Peptide

025-47 500 μg
EUR 102.6

Gastrin Related Peptide

027-09 5 mg
EUR 73.44

PGMtide Control Peptide

040-70 100 μg
EUR 316.44

Growth Blocking Peptide

046-92 100 μg
EUR 255.96

Neuron Specific Peptide

047-55 200 μg
EUR 140.4

Obesity Peptide Library

L-003 160 peptides
EUR 7267.32

[D-Ala1]-Peptide T

057-02 5 mg
EUR 282.96

Peptide YY (PYY) (Human)

059-01 200 μg
EUR 119.88

Eledoisin Related Peptide

046-04 5 mg
EUR 58.32

proSex peptide (28-55) - EIA Kit

EK-040-31 96 wells
EUR 603.72

Peptide F 1 (Lobster)

047-62 500 μg
EUR 73.44

Morphine Tolerance Peptide

050-13 1 mg
EUR 102.6

Phosphate Acceptor Peptide

058-24 500 μg
EUR 73.44

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human)

064-07 200 μg
EUR 114.48

Peptide I / pro-Histine-Rich Basic Peptide (HRBP) (1-26) (Aplysia brasiliana)

047-39 200 μg
EUR 444.96

Peptide II / pro-Histine-Rich Basic Peptide (HRBP) (29-40) (Aplysia brasiliana)

047-40 500 μg
EUR 214.92

Peptide I / pro-Histine-Rich Basic Peptide (HRBP) (1-26) (Aplysia californica)

047-42 200 μg
EUR 444.96

Peptide II / pro-Histine-Rich Basic Peptide (HRBP) (29-40) (Aplysia californica)

047-43 500 μg
EUR 214.92

FGL Peptide - Cy3 Labeled

FC3-073-36 1 nmol
EUR 672.84

FGL Peptide - Cy5 Labeled

FC5-073-36 1 nmol
EUR 756

FGL Peptide - FAM Labeled

FG-073-36A 1 nmol
EUR 405

Pedal Peptide (Pep) (Aplysia)

047-61 500 μg
EUR 177.12

ExE peptide M3mP6 mutant

064-35 200ug
EUR 234.36

ExE peptide M3mP6 mutant

064-37 200ug
EUR 234.36

FGL Peptide - FITC Labeled

FG-073-36B 1 nmol
EUR 405

AF-16 Peptide - Antibody

H-033-44 100 μl
EUR 336.96

Schizophrenia Related Peptide

047-79 5 mg
EUR 44.28

Insulin B (22-25) Peptide

035-08 5 mg
EUR 86.4

Eosinophilotactic Peptide (AGSE)

070-28 5 mg
EUR 27

Eosinophilotactic Peptide (VGSE)

070-29 5 mg
EUR 27

Cell Penetrating ARF Peptide (26-44)

068-56 500 μg
EUR 640.44

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine) - RIA Kit

RK-064-01 125 tubes
EUR 932.04

FGL Peptide - Biotin Labeled

B-073-36 20 μg
EUR 405

Peptide F (Bovine) - Antibody

H-024-58 50 μl
EUR 238.68

Brain Peptide (Bees) Library

L-007 51 peptides
EUR 6456.24

Gastrointestinal Peptide Library

L-006 200 peptides
EUR 7267.32

[D-Arg14, D-Arg15]-MGF Peptide amide / C-terminal peptide of IGF-1 Ec amide

033-34 100 μg
EUR 177.12

Peptide R / CXCR4 Antagonist

030-25 200 μg
EUR 203.04

PGMtide Peptide - Cy3 Labeled

FC3-040-69 1 nmol
EUR 925.56

PGMtide Peptide - FAM Labeled

FG-040-69A 5 nmol
EUR 537.84

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human) - Antibody

H-064-07 50 μl
EUR 238.68

[D-Ala1]-Peptide T amide

057-03 500 μg
EUR 140.4

Peptide F (Bovine) - RIA Kit

RK-024-58 125 tubes
EUR 932.04

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human) - RIA Kit

RK-064-07 125 tubes
EUR 932.04

Catch-Relaxing Peptide (CARP)

047-20 1 mg
EUR 199.8

Calmodulin Binding Peptide 1

070-17 20 μg
EUR 214.92

FGL Peptide - Rhodamine Labeled

FR-073-36 1 nmol
EUR 537.84

Peptide-Depleted Plasma (Rat)

MB-099-02 2 ml
EUR 119.88

Glycogenolysis-Inhibiting Peptide

023-63 500 μg
EUR 177.12

Anti-Inflammatory Peptide 1

004-01 200 μg
EUR 27

The Mitochondrial-Focused Peptide, SS31, Protects Murine 661W Cells from Oxidative Harm by way of Induction of Autophagy

The purpose of this research was to look at the impression of the mitochondrial-targeted antioxidant peptide, SS31, and its function in selling autophagy in cone photoreceptor 661W cells that had been subjected to oxidative harm. To take action, we examined the viability of 661W cells within the presence of accelerating concentrations of H₂O₂ with or with out SS31 pre-treatment utilizing the MTT assay and by expression of autophagy and apoptosis-associated proteins LC3-II/I, P62, and caspase-3.

Autophagy was evaluated by fluorescence microscopy in cells stained with monodansyl cadaverine (MDC). Autophagy was induced with rapamycin (Rap) and inhibited with bafamycin A1 (bafA1) adopted by examination of Reactive oxygen species (ROS) ranges in goal 661W cells by fluorescence microscopy and move cytometry. Annexin V/PI staining was used to judge the speed of apoptosis and mRNA sequencing (mRNA-seq) evaluation (Illumina platform) was carried out on H₂O₂-exposed 661W cells handled with SS31.

Amongst our outcomes, we noticed a considerable and concentration-dependent lower in 661W cell viability in response to H₂O₂-exposure; manufacturing of ROS, autophagy and apoptosis had been induced at Eight h in response to publicity to 100 μM of H₂O₂. Pre-treatment with 100 nM SS31 resulted in vital attenuation of HO-mediated cytotoxicity, along with decreased ROS manufacturing and enhanced autophagy noticed in response to oxidative stress.

Each Rap and bafA1 had been used to modulate SS31-mediated autophagy; the impression of Rap was much like that of SS31. Against this, administration of bafA1 counteracted autophagy induced by SS31. Moreover, mRNAseq evaluation revealed that SS31 promoted vital alterations in gene expression in 661W cells and urged that autophagy was induced by way of the mTORC1-mediated signaling.

In conclusion, our outcomes point out that publicity to H₂O₂ resulted in decreased 661W cell viability by way of mechanisms related to oxidative harm, apoptosis, and autophagy. Notably, we demonstrated that pre-treatment with SS31 protects 661W cells from H₂O₂-induced oxidative harm that will lead to half from induction of autophagy by way of mTORC1-mediated signaling pathways.

Hyaluronic acid-shelled, peptide drug conjugate-cored nanomedicine for the remedy of hepatocellular carcinoma

Peptide-drug conjugate (PDC) is a promising prodrug in drug supply methods. To manufacture nanostructures with correct molecular design which may self-assemble to spherical morphologies is essential for PDC chemotherapy. On this research, a novel PDC (PDC-DOX2), wherein two doxorubicin (DOX) molecules are conjugated onto a brief peptide (KIGLFRWR) with self-assembly operate, was designed and synthesized. PDC-DOX2 with self-assembly properties varieties a spherical construction underneath hydrophobic interplay in water.

 Hyaluronic acid (HA) was then coated on PDC-DOX2 micelles to kind a HA-shelled, peptide-doxorubicin conjugate-cored nanomedicine (HA@PDC-DOX2). The quantity of HA can regulate the particle dimension and stabilization of HA@PDC-DOX2. As well as, HA can actively improve the concentrating on results of PDC-DOX2 micelles since it will probably work together with overexpressed receptors in most cancers cells.

The core-shell structured HA@PDC-DOX2 nanomedicine confirmed considerably enhanced efficiency in opposition to hepatocellular carcinoma in comparison with PDC-DOX2 micelles in addition to free DOX. On this work, a novel PDC which may self-assemble to spherical morphologies and a core-shell construction HA@PDC-DOX2 nanomedicine are designed and ready. It gives a handy technique for the dimensions management of PDC assemblies and constructs efficient PDC-based drug supply methods for most cancers remedy.

CTRP7 Peptide

MBS153068-005mg 0.05mg
EUR 175

CTRP7 Peptide

MBS153068-5x005mg 5x0.05mg
EUR 770

Mast Cell-Degranulating Peptide (MCD Peptide) / Peptide 401

004-04 100 μg
EUR 140.4

CTRP6 Peptide

3575P 0.05 mg
EUR 197.7
Description: (CT) CTRP6 peptide

CTRP6 Peptide

3577P 0.05 mg
EUR 197.7
Description: (IN) CTRP6 peptide

CTRP1 Peptide

3555P 0.05 mg
EUR 197.7
Description: (IN) CTRP1 peptide

CTRP1 Peptide

3557P 0.05 mg
EUR 197.7
Description: (NT) CTRP1 peptide

CTRP2 Peptide

3559P 0.05 mg
EUR 197.7
Description: (IN) CTRP2 peptide

CTRP2 Peptide

3561P 0.05 mg
EUR 197.7
Description: (NT) CTRP2 peptide

CTRP3 Peptide

3565P 0.05 mg
EUR 197.7
Description: (IN) CTRP3 peptide

CTRP4 Peptide

3567P 0.05 mg
EUR 197.7
Description: (CT) CTRP4 peptide

CTRP4 Peptide

3569P 0.05 mg
EUR 197.7
Description: (IN) CTRP4 peptide

CTRP5 Peptide

3571P 0.05 mg
EUR 197.7
Description: (NT) CTRP5 peptide

CTRP5 Peptide

3573P 0.05 mg
EUR 197.7
Description: (IN) CTRP5 peptide

CTRP6 Peptide

MBS151976-005mg 0.05mg
EUR 175

CTRP6 Peptide

MBS151976-5x005mg 5x0.05mg
EUR 770

CTRP1 Peptide

MBS152035-005mg 0.05mg
EUR 175

CTRP1 Peptide

MBS152035-5x005mg 5x0.05mg
EUR 770

CTRP5 Peptide

MBS152063-005mg 0.05mg
EUR 175

CTRP5 Peptide

MBS152063-5x005mg 5x0.05mg
EUR 770

CTRP6 Peptide

MBS152087-005mg 0.05mg
EUR 175

CTRP6 Peptide

MBS152087-5x005mg 5x0.05mg
EUR 770

CTRP5 Peptide

MBS152140-005mg 0.05mg
EUR 175

CTRP5 Peptide

MBS152140-5x005mg 5x0.05mg
EUR 770

CTRP4 Peptide

MBS152271-005mg 0.05mg
EUR 175

CTRP4 Peptide

MBS152271-5x005mg 5x0.05mg
EUR 770

CTRP2 Peptide

MBS152414-005mg 0.05mg
EUR 175

CTRP2 Peptide

MBS152414-5x005mg 5x0.05mg
EUR 770

CTRP3 Peptide

MBS152457-005mg 0.05mg
EUR 175

CTRP3 Peptide

MBS152457-5x005mg 5x0.05mg
EUR 770

CTRP4 Peptide

MBS152506-005mg 0.05mg
EUR 175

CTRP4 Peptide

MBS152506-5x005mg 5x0.05mg
EUR 770

CTRP1 Peptide

MBS152726-005mg 0.05mg
EUR 175

CTRP1 Peptide

MBS152726-5x005mg 5x0.05mg
EUR 770

CTRP2 Peptide

MBS152939-005mg 0.05mg
EUR 175

CTRP2 Peptide

MBS152939-5x005mg 5x0.05mg
EUR 770

Peptide T

057-01 5 mg
EUR 140.4

FGL Peptide

073-36 100 μg
EUR 214.92

APK peptide

076-81 200 μg
EUR 199.8

NEF peptide

076-83 500 μg
EUR 140.4

SHA peptide

076-84 500 μg
EUR 177.12

YSY peptide

076-86 100 μg
EUR 230.04

Peptide E / 3200-Dalton Adrenal Enkephalin-Containing Peptide (Bovine)

024-57 200 μg
EUR 86.4

PSTAIR Peptide

070-61 500 μg
EUR 129.6

P59-Amide / CTRP8 (100-121)-Amide (Human)

036-40 100 μg
EUR 244.08

PGMtide Peptide

040-69 100 μg
EUR 316.44

Adjuvant Peptide

070-05 500 μg
EUR 36.72

Anti - CTRP7

MBS684121-002mL 0.02mL
EUR 270

Anti - CTRP7

MBS684121-005mL 0.05mL
EUR 405

Anti - CTRP7

MBS684121-01mL 0.1mL
EUR 585

Peptide-epsilon

058-22 500 μg
EUR 114.48

Delicious Peptide

070-21 5 mg
EUR 160.92

proSex peptide (20-55)

040-30 100 μg
EUR 355.32

proSex peptide (28-55)

040-31 100 μg
EUR 282.96

proSex peptide (40-55)

040-32 100 μg
EUR 214.92

Bombinin-Like Peptide 1 amide / prepro-Bombinin-Like Peptide (44-70) amide / prepro-Bombinin-Like Peptide (107-133) amide

007-60 100 μg
EUR 214.92

Peptide F-9

038-06 200 μg
EUR 58.32

Sturgeon Peptide (137-158)

021-94 100 μg
EUR 177.12

Peptide Lv (Rat)

008-73 100 μg
EUR 469.8

NGR Peptide 1

025-74 200 μg
EUR 184.68

CTRP3 Blocking Peptide

MBS9622335-1mg 1mg
EUR 380

CTRP3 Blocking Peptide

MBS9622335-5x1mg 5x1mg
EUR 1650

Anorexigenic Peptide

070-10 5 mg
EUR 86.4

GnRH Associated Peptide (GAP) (1-13) / GnRH Precursor Peptide (14-26) (Human)

029-03 500 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-24) / GnRH Precursor Peptide (14-37) (Human)

029-04 100 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-53) / GnRH Precursor Peptide (14-66) (Human)

029-05 20 μg
EUR 267.84

GnRH Associated Peptide (GAP) (25-53) / GnRH Precursor Peptide (38-66) (Human)

029-06 100 μg
EUR 114.48

Bid BH3 peptide

025-87 1 mg
EUR 170.64

AF-16 Peptide

033-44 200 μg
EUR 214.92

CTRP7 Antibody

24336 100ul
EUR 479

CTRP7 Antibody

24336-100ul 100ul
EUR 468

CTRP7 Antibody

24337 100ul
EUR 479

CTRP7 Antibody

24337-100ul 100ul
EUR 468

CTRP7 Antibody

24378 100ul
EUR 479

CTRP7 Antibody

24378-100ul 100ul
EUR 468

CTRP7 Antibody

3579-002mg 0.02 mg
EUR 206.18
Description: CTRP7 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Like the other members of the adiponectin and CTRP protein family, the mature CTRP7 is secreted and can be found in the organism's circulatory system.

CTRP7 Antibody

3579-01mg 0.1 mg
EUR 523.7
Description: CTRP7 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Like the other members of the adiponectin and CTRP protein family, the mature CTRP7 is secreted and can be found in the organism's circulatory system.

CTRP7 Antibody

3581-002mg 0.02 mg
EUR 206.18
Description: CTRP7 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Like the other members of the adiponectin and CTRP protein family, the mature CTRP7 is secreted and can be found in the organism's circulatory system.

CTRP7 Antibody

3581-01mg 0.1 mg
EUR 523.7
Description: CTRP7 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Like the other members of the adiponectin and CTRP protein family, the mature CTRP7 is secreted and can be found in the organism's circulatory system.

CTRP7 Antibody

3673-002mg 0.02 mg
EUR 206.18
Description: CTRP7 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Like the other members of the adiponectin and CTRP protein family, the mature CTRP7 is secreted and can be found in the organism's circulatory system.

CTRP7 Antibody

3673-01mg 0.1 mg
EUR 523.7
Description: CTRP7 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Like the other members of the adiponectin and CTRP protein family, the mature CTRP7 is secreted and can be found in the organism's circulatory system.

CTRP7 Antibody

MBS9409415-01mL 0.1mL
EUR 495

CTRP7 Antibody

MBS9409415-5x01mL 5x0.1mL
EUR 2075

CTRP7 Antibody

MBS9405968-01mL 0.1mL
EUR 495

CTRP7 Antibody

MBS9405968-5x01mL 5x0.1mL
EUR 2075

CTRP7 Antibody

MBS9408492-01mL 0.1mL
EUR 495

CTRP7 Antibody

MBS9408492-5x01mL 5x0.1mL
EUR 2075

CTRP7 Antibody

MBS150140-01mg 0.1mg
EUR 445

CTRP7 Antibody

MBS150140-5x01mg 5x0.1mg
EUR 1965

CTRP7 Antibody

MBS150434-01mg 0.1mg
EUR 445

CTRP7 Antibody

MBS150434-5x01mg 5x0.1mg
EUR 1965

CTRP7 Antibody

MBS150510-01mg 0.1mg
EUR 445

CTRP7 Antibody

MBS150510-5x01mg 5x0.1mg
EUR 1965

Peptide Lv (Human)

008-71 100 μg
EUR 405

Peptide Lv (Mouse)

008-72 100 μg
EUR 469.8

GnRH Associated Peptide (GAP) (1-13) / Gn-RH Precursor Peptide (14-26) (Rat)

029-08 200 μg
EUR 64.8

Peptide B (Bovine)

024-56 200 μg
EUR 81

Peptide F (Bovine)

024-58 200 μg
EUR 114.48

ExE peptide M3mP6

064-33 200 μg
EUR 244.08

PLP Peptide (103-116) (Bovine)

070-14 5 mg
EUR 140.4

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