Human RAD50(DNA Repair Protein RAD50) ELISA Kit
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Mouse DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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RDR-RAD50-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 668.4 |
Mouse DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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RDR-RAD50-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 928.8 |
Human DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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20-abx152916 | Abbexa |
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Human DNA repair protein RAD50, RAD50 ELISA KIT |
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ELI-22153h | Lifescience Market | 96 Tests | EUR 988.8 |
Human DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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SEK111Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5677.8 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human DNA Repair Protein RAD50 (RAD50) in Tissue homogenates and other biological fluids. |
Human DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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SEK111Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 572.76 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human DNA Repair Protein RAD50 (RAD50) in Tissue homogenates and other biological fluids. |
Human DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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SEK111Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 766.8 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human DNA Repair Protein RAD50 (RAD50) in Tissue homogenates and other biological fluids. |
Human DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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SEK111Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3090.6 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human DNA Repair Protein RAD50 (RAD50) in Tissue homogenates and other biological fluids. |
Human DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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4-SEK111Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human DNA Repair Protein RAD50 (RAD50) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species. |
Human DNA Repair Protein RAD50(RAD50)ELISA Kit |
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YLA3707HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human DNA Repair Protein RAD50(RAD50)ELISA Kit |
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YLA3707HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
DNA Repair Protein RAD50 (RAD50) Antibody |
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20-abx102551 | Abbexa |
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DNA Repair Protein RAD50 (RAD50) Antibody |
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20-abx102552 | Abbexa |
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DNA Repair Protein RAD50 (RAD50) Antibody |
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20-abx129886 | Abbexa |
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DNA Repair Protein RAD50 (RAD50) Antibody |
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abx224264-100ug | Abbexa | 100 ug | EUR 493.2 |
DNA Repair Protein RAD50 (RAD50) Antibody |
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20-abx176192 | Abbexa |
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Recombinant DNA Repair Protein RAD50 (RAD50) |
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4-RPK111Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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4-RPK111Hu02 | Cloud-Clone |
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Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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4-RPK111Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Repair Protein RAD50 expressed in: E.coli |
Human DNA Repair Protein RAD50 (RAD50) Protein |
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20-abx066357 | Abbexa |
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Human DNA Repair Protein RAD50 (RAD50) Protein |
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20-abx066358 | Abbexa |
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Mouse DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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20-abx154599 | Abbexa |
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Mouse DNA repair protein RAD50, Rad50 ELISA KIT |
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ELI-36118m | Lifescience Market | 96 Tests | EUR 1038 |
Mouse DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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SEK111Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5834.88 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse DNA Repair Protein RAD50 (RAD50) in tissue homogenates, cell lysates and other biological fluids. |
Mouse DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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SEK111Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 585.7 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse DNA Repair Protein RAD50 (RAD50) in tissue homogenates, cell lysates and other biological fluids. |
Mouse DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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SEK111Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 785.28 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse DNA Repair Protein RAD50 (RAD50) in tissue homogenates, cell lysates and other biological fluids. |
Mouse DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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SEK111Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3173.76 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse DNA Repair Protein RAD50 (RAD50) in tissue homogenates, cell lysates and other biological fluids. |
Mouse DNA Repair Protein RAD50 (RAD50) ELISA Kit |
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4-SEK111Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse DNA Repair Protein RAD50 (RAD50) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Mouse DNA Repair Protein RAD50(RAD50)ELISA Kit |
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YLA1585MO-48T | Shanghai YL Biotech | 48T | EUR 465 |
Mouse DNA Repair Protein RAD50(RAD50)ELISA Kit |
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YLA1585MO-96T | Shanghai YL Biotech | 96T | EUR 600 |
Human DNA Repair Protein RAD50 (RAD50) CLIA Kit |
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20-abx495821 | Abbexa |
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ELISA kit for Human RAD50 (DNA Repair Protein RAD50) |
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ELK4558 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
Description: A sandwich ELISA kit for detection of DNA Repair Protein RAD50 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
Mouse DNA Repair Protein RAD50 (RAD50) Protein |
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20-abx167833 | Abbexa |
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DNA Repair Protein RAD50 (RAD50) Antibody (Biotin) |
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20-abx272575 | Abbexa |
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Mouse DNA Repair Protein RAD50 (RAD50) CLIA Kit |
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20-abx495822 | Abbexa |
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DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human) |
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4-PAK111Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50) |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human) |
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4-PAK111Hu02 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50) |
ELISA kit for Mouse RAD50 (DNA Repair Protein RAD50) |
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ELK6574 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
Description: A sandwich ELISA kit for detection of DNA Repair Protein RAD50 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Mouse) |
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4-PAK111Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse DNA Repair Protein RAD50 (RAD50) |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), APC |
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4-PAK111Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with APC. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), Biotinylated |
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4-PAK111Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with Biotin. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), Cy3 |
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4-PAK111Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with Cy3. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), FITC |
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4-PAK111Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with FITC. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), HRP |
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4-PAK111Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with HRP. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), PE |
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4-PAK111Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with PE. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), APC |
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4-PAK111Hu02-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with APC. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), Biotinylated |
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4-PAK111Hu02-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with Biotin. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), Cy3 |
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4-PAK111Hu02-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with Cy3. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), FITC |
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4-PAK111Hu02-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with FITC. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), HRP |
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4-PAK111Hu02-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with HRP. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), PE |
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4-PAK111Hu02-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with PE. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Mouse), APC |
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4-PAK111Mu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse DNA Repair Protein RAD50 (RAD50). This antibody is labeled with APC. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Mouse), Biotinylated |
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4-PAK111Mu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse DNA Repair Protein RAD50 (RAD50). This antibody is labeled with Biotin. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Mouse), Cy3 |
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4-PAK111Mu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse DNA Repair Protein RAD50 (RAD50). This antibody is labeled with Cy3. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Mouse), FITC |
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4-PAK111Mu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse DNA Repair Protein RAD50 (RAD50). This antibody is labeled with FITC. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Mouse), HRP |
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4-PAK111Mu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse DNA Repair Protein RAD50 (RAD50). This antibody is labeled with HRP. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Mouse), PE |
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4-PAK111Mu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse DNA Repair Protein RAD50 (RAD50). This antibody is labeled with PE. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), APC-Cy7 |
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4-PAK111Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with APC-Cy7. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Human), APC-Cy7 |
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4-PAK111Hu02-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human DNA Repair Protein RAD50 (RAD50). This antibody is labeled with APC-Cy7. |
DNA Repair Protein RAD50 (RAD50) Polyclonal Antibody (Mouse), APC-Cy7 |
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4-PAK111Mu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse DNA Repair Protein RAD50 (RAD50). This antibody is labeled with APC-Cy7. |
RAD50 Double Strand Break Repair Protein (RAD50) Antibody |
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20-abx002219 | Abbexa |
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RAD50 Double Strand Break Repair Protein (RAD50) Antibody |
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20-abx014059 | Abbexa |
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RAD50 Double Strand Break Repair Protein (RAD50) Antibody |
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20-abx008360 | Abbexa |
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RAD50 Double Strand Break Repair Protein (RAD50) Antibody |
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abx224393-100ug | Abbexa | 100 ug | EUR 493.2 |
RAD50 Double Strand Break Repair Protein (RAD50) Antibody |
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abx332715-100ul | Abbexa | 100 ul | EUR 510 |
RAD50 Double Strand Break Repair Protein (RAD50) Antibody |
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20-abx328665 | Abbexa |
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RAD50 Double Strand Break Repair Protein (RAD50) Antibody |
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20-abx241091 | Abbexa |
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RAD50 Double Strand Break Repair Protein (RAD50) Antibody |
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20-abx241121 | Abbexa |
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RAD50 Double Strand Break Repair Protein (RAD50) Antibody |
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abx217060-100ug | Abbexa | 100 ug | EUR 526.8 |
Rad50/ Rat Rad50 ELISA Kit |
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ELI-30431r | Lifescience Market | 96 Tests | EUR 1063.2 |
RAD50 Antibody |
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1-CSB-PA075718 | Cusabio |
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Description: A polyclonal antibody against RAD50. Recognizes RAD50 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
RAD50 Antibody |
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1-CSB-PA003915 | Cusabio |
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Description: A polyclonal antibody against RAD50. Recognizes RAD50 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000 |
RAD50 Antibody |
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1-CSB-PA967370 | Cusabio |
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Description: A polyclonal antibody against RAD50. Recognizes RAD50 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
RAD50 Antibody |
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DF7176 | Affbiotech | 200ul | EUR 420 |
RAD50 siRNA |
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20-abx930769 | Abbexa |
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RAD50 siRNA |
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20-abx930770 | Abbexa |
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RAD50 Antibody |
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CSB-PA589951-100ul | Cusabio | 100ul | EUR 379.2 |
Description: A polyclonal antibody against RAD50. Recognizes RAD50 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000 |
RAD50 antibody |
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70R-50774 | Fitzgerald | 100 ul | EUR 292.8 |
Description: Purified Polyclonal RAD50 antibody |
RAD50 antibody |
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70R-33855 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal RAD50 antibody |
RAD50 antibody |
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38569-100ul | SAB | 100ul | EUR 302.4 |
RAD50 Antibody |
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34297-100ul | SAB | 100ul | EUR 302.4 |
RAD50 Antibody |
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34297-50ul | SAB | 50ul | EUR 224.4 |
RAD50 Antibody |
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31264-100ul | SAB | 100ul | EUR 302.4 |
RAD50 Antibody |
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31264-50ul | SAB | 50ul | EUR 224.4 |
Rad50 antibody |
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10R-8636 | Fitzgerald | 100 ul | EUR 471.6 |
Description: Mouse monoclonal Rad50 antibody |
RAD50 Antibody |
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ABD7176 | Lifescience Market | 100 ug | EUR 525.6 |
RAD50 Antibody |
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CSB-PA589951- | Cusabio | each | EUR 402 |
Description: A polyclonal antibody against RAD50. Recognizes RAD50 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000 |
RAD50 Antibody |
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RQ7032 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: DNA repair protein RAD50, also known as RAD50, is a protein that in humans is encoded by the RAD50 gene. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder. |
RAD50 ELISA Kit (Human) (OKCD00590) |
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OKCD00590 | Aviva Systems Biology | 96 Wells | EUR 997.2 |
Description: Description of target: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).6 Publications
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.7"The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response."_x005F_x005F_x000D_Carney J.P., Maser R.S., Olivares H., Davis E.M., Le Beau M., Yates J.R. III, Hays L., Morgan W.F., Petrini J.H.J._x005F_x005F_x000D_Cell 93:477-486(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN DSB REPAIR, IDENTIFICATION IN THE MRN COMPLEX WITH MRE11A AND NBN.Ref.8"Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95."_x005F_x005F_x000D_Trujillo K.M., Yuan S.-S.F., Lee E.Y.-H.P., Sung P._x005F_x005F_x000D_J. Biol. Chem. 273:21447-21450(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN DSB REPAIR, IDENTIFICATION IN THE MRN COMPLEX WITH MRE11A AND NBN.Ref.9"The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks."_x005F_x005F_x000D_Paull T.T., Gellert M._x005F_x005F_x000D_Mol. Cell 1:969-979(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, ATP-BINDING, MUTAGENESIS OF LYS-42 AND ASP-1231.Ref.13"Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres."_x005F_x005F_x000D_Zhu X.-D., Kuester B., Mann M., Petrini J.H.J., de Lange T._x005F_x005F_x000D_Nat. Genet. 25:347-352(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN TELOMERES, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE A COMPLEX WITH TERF2, SUBCELLULAR LOCATION.Ref.15"Human Rad50/Mre11 is a flexible complex that can tether DNA ends."_x005F_x005F_x000D_de Jager M., van Noort J., van Gent D.C., Dekker C., Kanaar R., Wyman C._x005F_x005F_x000D_Mol. Cell 8:1129-1135(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTRAMOLECULAR COILED-COIL DOMAINS.Ref.19"Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex."_x005F_x005F_x000D_Lee J.-H., Paull T.T._x005F_x005F_x000D_Science 304:93-96(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN ATM ACTIVATION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.057 ng/mL |
RAD50 ELISA Kit (Human) (OKDD00499) |
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OKDD00499 | Aviva Systems Biology | 96 Wells | EUR 1170 |
Description: Description of target: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.;Species reactivity: Human;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: < 0.057 ng/mL |
RAD50 ELISA Kit (Mouse) (OKCD00591) |
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OKCD00591 | Aviva Systems Biology | 96 Wells | EUR 1028.4 |
Description: Description of target: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).By similarity2 Publications
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.4"Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation."_x005F_x005F_x000D_Luo G., Yao M.S., Bender C.F., Mills M., Bladl A.R., Bradley A., Petrini J.H.J._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 96:7376-7381(1999) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, DISRUPTION PHENOTYPE.Ref.5"Cancer predisposition and hematopoietic failure in Rad50(S/S) mice."_x005F_x005F_x000D_Bender C.F., Sikes M.L., Sullivan R., Huye L.E., Le Beau M.M., Roth D.B., Mirzoeva O.K., Oltz E.M., Petrini J.H.J._x005F_x005F_x000D_Genes Dev. 16:2237-2251(2002) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, MUTAGENESIS OF LYS-22. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.059 ng/mL |
Rad50 Rabbit mAb |
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A3869 | Abclonal | 20 μL | EUR 18 |
Rad50 Rabbit mAb |
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A3869-100ul | Abclonal | 100 ul | EUR 492 |
Rad50 Rabbit mAb |
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A3869-200ul | Abclonal | 200 ul | EUR 685.2 |
Rad50 Rabbit mAb |
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A3869-20ul | Abclonal | 20 ul | EUR 265.2 |
Rad50 Rabbit mAb |
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A3869-50ul | Abclonal | 50 ul | EUR 344.4 |
RAD50 Blocking Peptide |
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DF7176-BP | Affbiotech | 1mg | EUR 234 |
RAD50 Conjugated Antibody |
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C31264 | SAB | 100ul | EUR 476.4 |