Description: tissue homogenates, cell lysates and other biological fluids.

Description: tissue homogenates, cell lysates and other biological fluids.

Description: tissue homogenates, cell lysates or other biological fluids.

Description: tissue homogenates, cell lysates or other biological fluids.

Description: tissue homogenates, cell lysates and other biological fluids.

Description: tissue homogenates, cell lysates and other biological fluids.

Description: A sandwich ELISA kit for detection of Cylindromatosis from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Description: Recombinant Human Cylindromatosis expressed in: E.coli

Description: A Rabbit polyclonal antibody against Human Cylindromatosis (CYLD)

Description: Human Cylindromatosis ELISA Kit

Description: A Rabbit polyclonal antibody against Human Cylindromatosis (CYLD). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Human Cylindromatosis (CYLD). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human Cylindromatosis (CYLD). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human Cylindromatosis (CYLD). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human Cylindromatosis (CYLD). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human Cylindromatosis (CYLD). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Human Cylindromatosis (CYLD). This antibody is labeled with Biotin.

Description: Description of target: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity).By similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:Q80TQ2 (CYLD_MOUSE)10 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.6"CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members."_x005F_x005F_x000D_Trompouki E., Hatzivassiliou E., Tsichritzis T., Farmer H., Ashworth A., Mosialos G._x005F_x005F_x000D_Nature 424:793-796(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH IKBKG/NEMO, MUTAGENESIS OF CYS-601.Ref.7"Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB."_x005F_x005F_x000D_Brummelkamp T.R., Nijman S.M.B., Dirac A.M.G., Bernards R._x005F_x005F_x000D_Nature 424:797-801(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH IKBKG/NEMO, MUTAGENESIS OF CYS-601.Ref.8"The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination."_x005F_x005F_x000D_Kovalenko A., Chable-Bessia C., Cantarella G., Israeel A., Wallach D., Courtois G._x005F_x005F_x000D_Nature 424:801-805(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH IKBKG/NEMO AND TRAF2, MUTAGENESIS OF SER-457 AND HIS-871.Ref.9"The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor."_x005F_x005F_x000D_Regamey A., Hohl D., Liu J.W., Roger T., Kogerman P., Toftgaard R., Huber M._x005F_x005F_x000D_J. Exp. Med. 198:1959-1964(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TRIP.Ref.11"The tumor suppressor CYLD regulates entry into mitosis."_x005F_x005F_x000D_Stegmeier F., Sowa M.E., Nalepa G., Gygi S.P., Harper J.W., Elledge S.J._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 104:8869-8874(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, MUTAGENESIS OF CYS-601, INTERACTION WITH PLK1, SUBCELLULAR LOCATION.Ref.12"The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response."_x005F_x005F_x000D_Friedman C.S., O'Donnell M.A., Legarda-Addison D., Ng A., Cardenas W.B., Yount J.S., Moran T.M., Basler C.F., Komuro A., Horvath C.M., Xavier R., Ting A.T._x005F_x005F_x000D_EMBO Rep. 9:930-936(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, INTERACTION WITH DDX58; MAVS; TBK1 AND IKKE.Ref.13"The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration."_x005F_x005F_x000D_Gao J., Huo L., Sun X., Liu M., Li D., Dong J.T., Zhou J._x005F_x005F_x000D_J. Biol. Chem. 283:8802-8809(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION.Ref.15"CYLD regulates angiogenesis by mediating vascular endothelial cell migration."_x005F_x005F_x000D_Gao J., Sun L., Huo L., Liu M., Li D., Zhou J._x005F_x005F_x000D_Blood 115:4130-4137(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION.Ref.16"CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin."_x005F_x005F_x000D_Wickstrom S.A., Masoumi K.C., Khochbin S., Fassler R., Massoumi R._x005F_x005F_x000D_EMBO J. 29:131-144(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH HDAC6; BCL3 AND MICROTUBULES, SUBCELLULAR LOCATION.Ref.17"Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl."_x005F_x005F_x000D_Tauriello D.V., Haegebarth A., Kuper I., Edelmann M.J., Henraat M., Canninga-van Dijk M.R., Kessler B.M., Clevers H., Maurice M.M._x005F_x005F_x000D_Mol. Cell 37:607-619(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH DVL1 AND DVL3. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.115 ng/mL

Description: Recombinant Human protein for CYLD